Study on the Effect of Oral Administration of Marine Collagen Peptides on Epidermal Water and Chloasma_West China Medical Journal

Authors：

PAN Xingchang ¹ , GE Wenjin ² , LIU Yuan ³ , XU Yaguang ¹ , GU Ruizeng ¹ , CAI Muyi ¹ ,  HU Wen ³

1. China National Research Institute of Food & Fermentation Industries, Beijing 100027, P. R. China; 2. Department of Medicine, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, P. R. China; 3. Clilical Nutritional Department, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

HU Wen, Email: nutripan@163.com

Keywords：

海洋鱼皮胶原肽; 皮肤水份; 黄褐斑

DOI：

CNKI: 51-1356/R.20120214.1531.042

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目的　探讨口服海洋鱼皮胶原肽对人体皮肤水份和面部黄褐斑的影响。方法　选择年龄在30～65岁、皮肤水份≤12者100名和年龄在18～65岁、面部有黄褐斑者100名，分别随机分为试验组和对照组（各50名），进行改善皮肤水份试验、祛黄褐斑试验。受试者每天摄入海洋鱼皮胶原肽2.7 g，连续30 d。在试验前后分别测定皮肤水份、面部黄褐斑的面积和颜色，调查受试者疲劳感、烦躁、睡眠、干涩等不适症状的变化，测定血常规、大小便常规和血液生化指标。结果　皮肤干燥者口服海洋鱼皮胶原肽后，皮肤水份由（7.48 ± 2.39）增加至（8.68 ± 3.15），得到明显改善（P＜0.05），与对照组相比差异具有统计学意义（P＜0.01）；而对皮肤的油份和pH值没有影响（P＞0.05）。面部有黄褐斑者口服海洋鱼皮胶原肽后，黄褐斑的色卡值平均降低（0.35 ± 0.38）度，黄褐斑的面积平均缩小（4.70 ± 8.01） cm2。与试验前比较，两项指标均有明显变化（P＜0.01）；与对照组相比，两项指标差异有统计学意义（P＜0.05）。两组试验中，受试者疲劳感、烦躁、睡眠、干涩等不适症状均有明显改善；血常规、大小便常规和血液生化检查结果均无明显异常，亦未见过敏反应。结论　口服海洋鱼皮胶原肽能够改善皮肤水份和祛面部黄褐斑，并有助于改善疲劳感、烦躁、睡眠、干涩等不适症状。

Citation： PAN Xingchang ,GE Wenjin,LIU Yuan,XU Yaguang,GU Ruizeng,CAI Muyi,HU Wen. Study on the Effect of Oral Administration of Marine Collagen Peptides on Epidermal Water and Chloasma. West China Medical Journal, 2012, 27(2): 218-222. doi: CNKI: 51-1356/R.20120214.1531.042 Copy

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10.	宋永相, 孙谧, 王跃军, 等. 海洋活性胶原肽的抗氧化性及对酪氨酸酶的抑制作用与初步分离研究[J]. 中国食品学报, 2009, 9(5): 7-12.
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1. Parry DA, Craig AS, Barnes GR. Tendon and ligament from the horse: an ultrastructural study of collagen fibrils and elastic fibers as a function of age[J]. Proc R Soc Lond B Biol Sci, 1978, 203(1152): 293-303.
2. 王军波, 谢英, 裴新荣, 等. 海洋鱼皮胶原肽的分子组成及其降血脂和抗氧化作用研究[J]. 中华预防医学杂志, 2008, 42(4): 226-230.
3. 裴新荣, 杨睿悦, 张召锋, 等. 海洋鱼皮胶原肽抗皮肤老化作用的实验研究[J]. 中华预防医学杂志, 2008, 42(4): 235-238.
4. 李国英, 张忠楷, 雷苏, 等. 胶原、明胶和水解胶原蛋白的性能差异[J]. 四川大学学报(工程版), 2005, 37(4): 54-58.
5. 张忠楷, 李国英. 胶原、明胶和水解胶原蛋白的护肤功能比较[J]. 日用化学工业, 2006, 36(1): 18-21.
6. Koyama Y, Shita A, Kuwaba K, et al. Effects of oral ingestion of collagen peptide on the skin[J]. Fragr J, 2006, 34(6): 82-85.
7. Iwai K, Hasegawa T, Taguchi Y, et al. Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hydrolysates[J]. J Agric Food Chem, 2005, 53(16): 6531-6536.
8. 蒋挺大. 胶原与胶原蛋白[M]. 北京: 化学工业出版社, 2006: 256-258.
9. Ohara H, Matsumoto H, Ito K, et al. Comparison of quantity and structures of hydroxyproline-containing peptides in human blood after oral ingestion of gelatin hydrolysates from different sources[J]. J Agric Food Chem, 2007, 55(4): 1532-1535.
10. 宋永相, 孙谧, 王跃军, 等. 海洋活性胶原肽的抗氧化性及对酪氨酸酶的抑制作用与初步分离研究[J]. 中国食品学报, 2009, 9(5): 7-12.
11. Olson GB, Savage S, Olson J. The effects of collagen hydrolysat on symptoms of chronic fibromyalgia and temporomandibular joint pain[J]. Cranio, 2000, 18(2): 135-141.
12. Jacobsen S, Jensen LT, Foldager M, et al. Primary fibromyalgia: clinical parameters in relation to serum procollagen type Ⅲ aminoterminal peptide[J]. Br J Rheumatol, 1990, 29(3): 174-177.

West China Medical Journal

Study on the Effect of Oral Administration of Marine Collagen Peptides on Epidermal Water and Chloasma

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